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Digestive Health

Manipulating the Human Microbiome to Protect Against Flu

Jan 21 by Ewcopywriting

The last few years have brought a flood of new knowledge about the role of gut bacteria in whole-body health. However, the gut is not the only area of our body in which a healthy balance of bacteria can make a measurable difference in wellness.

We now know that a diverse and healthy microbiome can be a benefit not just to our digestive tract, but to our immune system, mood and even neurological function. According to a new study, small changes in our natural bacteria may even protect against flu and other contagious illnesses. Have you taken your probiotics today? If not, it may be time.

The Ancient — and Modern — Threat of Influenza

Manipulating the Human Microbiome to Protect Against Flu 2Although most people have gotten the flu and recovered, it is actually one of the greatest disease threats of our time. Before knowledge about sanitation and widespread vaccination made flu less common, millions of people would die from this disease in just one flu season. Even in modern times, the flu is a very real risk to children, the elderly and people with compromised immune systems. In addition, it can cause a week or more of high fever and other serious symptoms even in the healthiest among us.

Scientists and doctors have managed to mitigate the risk of influenza in several ways. First, widespread vaccination efforts every season keep the most dangerous strains from developing into pandemics. Second, there are antiviral medications that can lessen the severity of illness and decrease the amount of time it takes to recover. Third, widespread hand-washing and other sanitation efforts have helped to reduce the incidence of flu.

These efforts have made a marked difference, but this is not enough. Influenza season every year brings reports of hundreds of deaths, some in people who were otherwise healthy. In fact, an average of 650,000 people die from influenza every year. According to new research, changing our microbiome just slightly may form another layer of protection — one that is sorely needed in an age of “super bugs” that are resistant to most medical efforts.

Could Your Respiratory Tract Bacteria Protect Against Flu?

Influenza infections begin when the virus colonizes the delicate mucus membranes of the respiratory tract. These mucus membranes are already colonized with a variety of bacteria that contribute to our health in different ways. A group of researchers wondered: Could changing this bacterial balance help to protect against influenza?

To answer this question, the researchers took a group of people who were not ill but had a member of their household recently diagnosed with influenza. Living with someone who has the flu almost guarantees exposure. Each person had a swab taken of their nose and throat to determine the makeup of their respiratory bacteria. They then watched to see which people developed influenza.

People with certain types of respiratory bacteria were far less likely to develop influenza than people with specific types of staphylococcus and streptococcus. This suggests that slightly changing our natural bacteria balance may help to protect against the flu and other serious viruses.

Your Microbiome and Your Health

The lead author of this study, Professor Betsy Foxman, stated, “I love the idea of working with our microbes as opposed to seeing them as an enemy that needs to be eradicated.” A great deal of research has focused on the importance of our gut flora in our health. However, this is not the only microbial population that is important. Our bodies are covered in bacteria, all of which has an effect in some way. Bacteria on our skin help to keep a healthy biochemical balance and prevent infections, for example. The new research on respiratory bacteria is one of several studies showing us the impact of the bacteria in our nose and respiratory tract.

We evolved to live symbiotically with many of the organisms in our environment. It should not come as a surprise that many of the bacteria in our surrounding are more friends than foes. There are more than 40 million bacteria on and in our bodies at any given time; more than the sum total of our human cells. Manipulating these bacteria may be beneficial in a variety of ways even beyond helping us to prevent common illnesses.

Feeding Your Flora

Manipulating the Human Microbiome to Protect Against Flu 1Hippocrates, father of modern medicine and writer of the famous Hippocratic oath, once noted, “Let food be thy medicine and medicine be thy food.” However, the modern Western diet does more to harm our microflora than to help it. We eat meat that has been fed antibiotics, which we then absorb. We clean our houses from top to bottom with antimicrobial cleansers. Americans also do not ingest adequate amounts of traditional fermented foods, which are teeming with healthy probiotic organisms.

Many people are making up for this deficit by taking probiotic supplements. While this is important, it may not be enough. Significant research suggests that it is also important to take prebiotic supplements, which are made up of the soluble fiber that helps healthy bacteria to thrive.

There is a huge and growing body of evidence that suggests that maintaining a healthy bacterial balance is essential to good health. Whether you feed your microbiome with fermented foods or carefully designed supplements, keeping a thriving microbial population could be essential to your well-being in a variety of ways.

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Filed Under: Diet & Nutrition, Digestive Health, Immune System Health

IBD and Prostate Cancer Linked, Says New Study

Jan 11 by Ewcopywriting

The prostate gland is a small organ that’s shaped like a walnut. This gland is responsible for producing seminal fluid, the liquid that transports sperm within a man’s body. This small but crucial gland is the site of one of the most common forms of cancer to afflict men — prostate cancer. When prostate cancer remains confined to the prostate gland, it usually causes little trouble. In fact, it’s not always necessary to treat this type of cancer, and when treatment is pursued, it involves minimally invasive techniques. A problem can arise, however, when the cancer starts to spread beyond the prostate gland. In these cases, more aggressive forms of treatment are required.

Recently, new research has identified a strong correlation between IBD (inflammatory bowel disease) and prostate cancer. As men age and face this risk, prostate health becomes a larger concern.

Prostate Cancer Symptoms and Treatment

IBD and Prostate Cancer Linked, Says New Study 2All men should be able to identify the common symptoms of prostate cancer. If one or more of the following symptoms are experienced, consult a doctor as soon as possible to rule out a serious cause:

  • difficulty urinating
  • decrease in the force of the urine stream
  • blood mixed with semen
  • bone pain or discomfort around the pelvic region
  • erectile dysfunction

One of the most common ways to treat prostate cancer is to remove the gland and some of the surrounding tissue. During the procedure, the surgeon will likely remove a few lymph nodes in the area as well, so the risk of a recurrence is minimized. Alternative methods of treatment include radiation and chemotherapy. Once the cancer is either removed or destroyed, the doctor may prescribe hormone therapy to block the release of testosterone. The prostate gland relies on testosterone to function, which is why prostate cancer cells can be affected by the absence of the hormone. Without testosterone, any lingering cancer cells will grow at a slower rate and may ultimately die.

There are many more treatment options available. If you do develop prostate cancer, discuss your options with your doctor. He may recommend multiple approaches to ensure the cancer is eliminated. Certain treatments can also reduce your risk of getting prostate cancer again.

New Study Links IBD and Prostate Cancer

While we know that age, diet, race and genetics play a part in raising the risks of developing this form of cancer, new research has also discovered that IBD may also play a part. IBD affects the gastrointestinal system, causing symptoms such as diarrhea, cramps and bloating. Both men and women can develop IBD and, as the CDC reports, more than three million people suffer from it annually. While it has been known that IBD raises the risk of cancer growing in the gastrointestinal tract, the link between IBD and prostate cancer had not been previously studied. A team at Chicago’s Northwestern Medicine sought to change that with a new research project.

The idea of a link between IBD and prostate cancer was already suggested in the way prostate cancer is diagnosed: Doctors use prostate specific antigens (PSA) to determine the presence of cancer. Since PSA levels are normally low, a spike indicates that cancer may be present. The problem is that men suffering from IBD also have a high PSA count. Doctors attribute this to the chronic inflammation that characterizes IBD.

To learn more about if and how the two conditions are related, the researchers compared 1,033 men with IBD against a control group of 9,306 men without the disease. As the project began, the men had an average age of 53; the two groups were studied for 18 years. By the end of the project, the researchers discovered a startling correlation between IBD and prostate cancer. Those men with IBD were five times more likely to develop prostate cancer than their healthier counterparts.

While more research may uncover evidence to explain this correlation, the research team has a theory. They believe the medication used to treat IBD may be the culprit. The body’s immune system seeks out and destroys cancer cells before they can grow, but IBD medication inhibits the immune system. It has also been suggested that IBD and prostate cancer share genetic links, which may also explain the correlation.

Keeping Your Prostate Healthy Naturally

It’s never too early to adjust your diet and lifestyle to take prostate health into consideration. There are a number of natural ways to protect prostate health:

Eat More Foods Rich in Flavonoids

Flavonoids are miracle compounds that deliver powerful antioxidants to the body. Flavonoids possess anti-carcinogenic and anti-inflammatory properties, which may be why people who ingest flavonoid-rich foods and drinks are less likely to develop cancer. Studies have found that flavonoids may prevent prostate cancer, while killing prostate cancer cells that have started to grow. Green tea, fruits, vegetables and whole grains are rich in flavonoids.

Consume More Soy

Soy and soy byproducts are rich in phytoestrogens, which are a type of phytohormone found in plant-based foods. While not as strong as estrogen, phytoestrogens may be able to counteract the effect of testosterone in the prostate gland. In Japan, where soy is most commonly consumed, the men have a significantly lower rate of prostate cancer.

Eat More Tomatoes

IBD and Prostate Cancer Linked, Says New Study 1Regardless of how they’re prepared, tomatoes are believed to prevent a range of cancers from developing. The presence of a compound called lycopene gets the credit for this. Studies suggest it’s especially effective in preventing prostate, stomach and lung cancer.

Drink More Coffee

The rush of antioxidants that coffee delivers to the blood stream is believed to prevent many types of cancer, including prostate cancer. Those antioxidants attack the free radicals in the body that are responsible for cancer cells. Adding more antioxidants to your diet may be one of the best ways to prevent some forms of cancer.

There are some risk factors that simply can’t be altered, when it comes to prostate cancer. For instance, older men and black males are far more likely to develop prostate cancer. That doesn’t mean you can’t act to decrease your risk of developing the disease. Paying closer attention to your food choices and being wary of the symptoms may help you lower your risks and identify problems earlier.

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Filed Under: Cellular Health, Digestive Health, Men's Health, Prostate Health

New Diabetes Research Finds Link to Gut Health and Cognitive Decline

Jan 09 by Ewcopywriting

Diabetes is a serious disease that affects the body’s ability to properly handle glucose, or sugar, in the blood. In type 1 diabetes, the body is unable to produce any insulin — the hormone responsible for ushering sugar from the blood into the cells where it can be used for energy. In type 2 diabetes, the body can make insulin but the cells are unable to properly utilize the insulin. Both type 1 and type 2 diabetes result in too-high levels of glucose in the bloodstream.  Over time, high levels of sugar in the bloodstream can negatively affect the heart, kidneys, nerves, eyes and more.

Type 1 diabetes, whose exact cause is unknown, is usually acquired at a young age and is irreversible. Type 2 diabetes, however, is often attributed to diet and lifestyle factors and can be reversed in certain cases. Some common symptoms of diabetes include excessive thirst, frequent urination, fatigue, slow wound healing, blurred vision and unintended weight loss. As new diabetes research uncovers links to cognitive decline and gut health, the emphasis falls on preventing and controlling type 2 diabetes.

New Study Looks at a Correlation Between Type 2 Diabetes and Cognitive Decline

New Diabetes Research Finds Link to Gut Health and Cognitive Decline 1Recently, a team of University of Tasmania researchers led by Michele Callisaya conducted a study to find out why cognitive decline is prevalent in people with type 2 diabetes. The project looked at 705 adults between the ages of 55 and 90. The testing included brain size measurements as well as cognition evaluations.

Of the 705 participants, 348 suffered from type 2 diabetes, while 357 exhibited no signs of the illness. MRI scans of all participants were used to measure the ventricular and total brain mass on an effort to link brain atrophy and type 2 diabetes. The level of cognitive functioning was also examined, with testing conducted periodically over the 4.6 years of the study. Ms. Callisaya and her team adjusted the research to account for contributing factors, such as age, gender and health status.

The findings suggested that brain atrophy has no bearing on how diabetes affects cognitive decline. They also found that brain atrophy was similar among those with and without type 2 diabetes. It was noted, however, that the subjects with type 2 diabetes already had more advanced atrophy at the beginning of the study.

This new diabetes research also showed that cognitive decline was affected by diabetes. Specifically, those without diabetes exhibited improved verbal fluency over the course of the study, while the diabetic subjects showed a notable decline. This was a point of concern in the University of Tasmania study, because everyday activities, such as adhering to medication schedules, may be affected. Callisaya concluded that verbal fluency and memory decline gradually over a five year period in people with type 2 diabetes.

New Diabetes Research Suggests Gut Bacteria Affects Diabetes Medication

While we have multiple medications to help treat type 2 diabetes, the effectiveness of those drugs varies from person to person. This means a large number of the 415 million diabetes sufferers may not experience adequate relief from those drugs. Until now, there was no way to know why the effectiveness of the drugs varies to such an extreme degree. Working out of Winston-Salem, Hariom Yadav, Ph.D led a study to see if gut bacteria played a role in altering the effectiveness of diabetes medications.

The possibility of gut bacteria playing a role in how well diabetes medication worked seemed plausible because researchers know from previous studies that an abnormal balance of gut bacteria can be a contributory factor in obesity and type 2 diabetes. Additionally, it has been found that drugs taken orally can be ineffective, while the intravenous medications work more often. This is partially due to the fact that drugs taken orally must pass through the gut to work, raising suspicions that something happened in the gut to affect the drugs.

Through testing, the researchers found that they could alter the effectiveness of diabetes medication by manipulating the gut microbiome. Depending on how the microbiome was altered, the effectiveness of the drugs was either improved or reduced. Hariom Yadav concluded that the metabolic capacity of the gut microbiome affected how well the medication was absorbed. It could also alter the nature of the drug, making it more effective, rendering it inert or making it toxic to the patient. While this research did point to a correlation, Mr. Yadav says more research is needed. This field of study is still young, but, with additional research, we may learn more about how gut bacteria affects diabetes medications. This knowledge may even help us treat diabetics more effectively.

Taking Steps to Prevent Diabetes

If you don’t have type 2 diabetes now, it’s important to make sure you’re doing all you can to prevent it. Making just a few lifestyle changes can keep you from developing this disease. Even if you have been diagnosed with type 2 diabetes these same changes may help you to better control your condition.

Get More Exercise

New Diabetes Research Finds Link to Gut Health and Cognitive Decline 2Increasing the amount of physical activity you get on a daily basis can help you prevent diabetes in a number of ways. Since obesity is linked to diabetes, losing weight is an excellent way of preventing the illness. Additionally, regular physical activity lowers blood sugar levels, while also improving your body’s sensitivity to insulin.

Eat More Fiber

You may know that fiber intake is related to heart health, but research shows that it also assists in regulating blood sugar levels. Since fiber helps you feel full for longer, consuming more may also contributes to weight loss.

Eat More Whole Grains

Whole grains also play a big role in diabetes prevention, though we don’t know why as of yet. We do know that people who switch to whole grains exhibit better blood sugar levels. Look for whole grains in breads, cereals, pasta and rice.

Take a Daily Supplement

If you want to get better control over your blood sugar, turning to a supplement may help. It will require choosing a supplement that contains the right ingredients, however. Chromium picolinate, banaba leaf, bitter melon, gymnema, fenugreek and vanadium are all ingredients that have been shown to help maintain healthy blood sugar levels within normal ranges.

Get Better Sleep

Research has also found that poor sleep patterns affect how blood glucose is processed. Looking for ways to resolve sleep disorders can help you protect against developing diabetes. Try relaxation techniques or improving your sleeping quarters to eliminate restlessness.

Diabetes research continues to move forward, uncovering more about how other conditions affect the development of the disease. In the meantime, we can use what we have already learned to help control and prevent the disease. Lifestyle changes and even changing how we take medication can help diabetics live a better quality of life.

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Filed Under: Aging, Blood Sugar/Glucose Metabolism, Cognition, Digestive Health

New Research Into Omega-3 and Colon Cancer Shows Possible Benefits

Dec 10 by Ewcopywriting

Colorectal cancer amounts for about 700,000 deaths worldwide. Could taking a daily dose of a certain supplements offer protection while also promoting stronger brain and heart health? A new study from the UK called the 2018 seAFOod Trial that discovered a link between aspirin, omega-3 and colon cancer supports this theory.

Colon Cancer, Polyps, and Pre-cancerous Conditions

New Research Into Omega-3 and Colon Cancer Shows Possible Benefits 2The National Cancer Institute anticipates over 140,000 new cases of colon-related cancer in the U.S. by the end of 2018. Colon cancer affects men and women equally, with the average age of diagnosis being 67. The current mortality rate is 14 percent. Colon cancer typically begins with adenomatous polyps (adenomas), but their presence alone isn’t enough for a cancer diagnosis. People can have these pre-cancerous polyps and never have cancer. However, their presence in the colon does greatly increase a person’s risk for developing colorectal-types of cancer. Other risk factors include polyp size, the number of polyps and dysplasia after a biopsy. Age and lifestyle are the two largest risk factors for colon cancer. Family history of colorectal cancer is the third leading factor, followed by other bowel related diseases.

Prevention and Early Detection

The prevention and early detection of cancer have become growing areas of study. These various preventive measures are popular among high-risk populations, but colon cancer doesn’t appear to disparage by race or sex, though some studies suggest a higher prevalence in men and African Americans.

Doctors recommend lifestyle changes at the earliest signs of pre-cancerous conditions, patient-revealed family history or diagnosis. The recommendations made wholly depend on the patient’s current lifestyle, but some suggestions could be to increase physical activity, overhauling the diet, quitting smoking and taking certain supplements.

Understanding the Role of Omega-3 Fatty Acid in Colon Cancer Prevention and Treatments

Taking omega-3 fatty acids might not be enough to prevent cancer alone, according to this review of available research at the time (which doesn’t take the new 2018 UK study into account). However, their overall health benefits to the heart, brain and digestive system when utilized along with healthy lifestyle changes and diet can provide essential building blocks for disease prevention.

Most omega-3 studies revolve around fish oil supplements or marine sources. One problem here is dissecting the omega-3 fatty acid chains and studying individual ones. Regardless, the eicosapentaenoic acid (EPA) in omega-3 has shown promising results in studies for treating early colorectal cancer stages. It may also provide benefits for later stages as well as prevention. A treatment plan that includes EPA can also work alongside chemotherapy without adverse side effects.

What science and medicine know about omega-3 chains as a whole is that they help modulate inflammation in the body — and inflammation and colon cancer do seem to share a link. Some research has suggested that omega-3 fatty acids may have the ability to affect cancer cells and tumor size, but more studies are needed.

Omega-3 and Colon Cancer Prevention and Disease Mortality Decline

In the recent pre-cancerous polyp study that used aspirin and omega-3 supplements, four groups of participants were studied. Among the four groups, one group took aspirin and omega-3 supplements. Another took only aspirin while a third used only omega-3 supplements. The fourth group was a control. This particular study found that the combination of omega-3 and aspirin appeared to reduce the size of pre-cancerous polyps.

Two U.S.-based studies also analyzed data from high-risk men and women taking preventative treatments with or without a colon cancer diagnosis. During the extensive studies, over 1,600 people developed cancer, and over 500 of those passed away due to their disease. The participants who obtained a diagnosis and consumed omega-3 from fish sources saw a decrease in mortality rate. Scientists noted that among those who changed their dietary habits to include more omega-3 fatty acids after their diagnosis also had a reduction in death rate.

Concerns Over Aspirin and Omega-3 EPA Use

New Research Into Omega-3 and Colon Cancer Shows Possible Benefits 1Doctors do raise concerns over taking a high dose of aspirin (300 mg) on an ongoing basis, which can cause internal bleeding. The study doesn’t include data for those with increased bleeding disorders, allergies to aspirin or stomach ulcers.

Aside from a temporary upset stomach and a fishy aftertaste, no known side effects or concerns arise with using dietary or therapeutic doses of omega-3 supplements. Some non-symptom concerns are the quality and increased caloric intake from supplements. High intakes beyond the scope of colon cancer studies do carry an increased risk of bleeding and possibly stroke. The new research shows promise when it comes to both treatment options and mortality rates in those with colon cancer. More studies could help further define the benefits when it comes to prevention and reoccurence rates as well.

Current guidelines suggest daily intake of omega-3 rich foods and taking supplements under a doctor’s guidance. For people who are at high risk of colon cancer, they should speak with their doctor about using the aspirin and/or aspirin and omega-3 therapy as a preventative measure. They should also be sure to continue with normal checkups and screening to catch any changes early.

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Filed Under: Cellular Health, Diet & Nutrition, Digestive Health

Black Pepper Extract Benefits: Boost Nutrient Absorption and More

Nov 28 by Ewcopywriting

The black pepper plant produces a unique fruit that is harvested and used to create black pepper, a substance used all over the world daily. In fact, many people add black pepper to their foods so frequently that they don’t even think about it. This has made it one of the most valued spices in the world for generations. After harvesting, the fruit of the plant is dried, resulting in what we know as the peppercorn — a tiny seed-like ball with potent anti-inflammatory and anti-bacterial properties. The fruit of the black pepper plant is of such interest to scientists because its primary element is piperine. The piperine in black pepper is what gives it its powerful scent and flavor, but it does much more than simply improve the taste of food. The piperine in black pepper can help the body in a number of ways, from helping to better absorb nutrients to alleviating dental discomfort.

Science Takes a Deeper Look at Black Pepper

Black Pepper Extract Benefits: Boost Nutrient Absorption and More 2One of the newest discoveries is that black pepper extract benefits include helping the body process nutrients more efficiently. It does this by slowing down processes in the liver and intestines, allowing certain compounds to be held in the intestines longer. This gives the body more time to absorb nutrients, which allows the digestive system an opportunity to make better use of the foods we eat. Specifically, a process called “glucuronidation” is inhibited when piperine is added to the system. Under normal circumstances, glucuronidation helps the liver process medications and dietary supplements more rapidly. This process causes the beneficial properties of these substances to be flushed out with our urine prematurely. By arresting this process, the black pepper extract gives the body a longer period during which it can absorb these helpful properties of nutrients, vitamins and minerals that are ingested.

Black pepper extract benefits are particularly beneficial where curcumin is concerned. Curcumin is another natural substance, found in spices like turmeric, that provides a wealth of health benefits. However, our bodies can’t absorb curcumin quickly enough and many of the beneficial properties are flushed out of the system as waste. When black pepper extract is added to the mix, it slows down the digestive system long enough to allow the body to absorb more of the healthy properties found in curcumin. Taking black pepper extract with curcumin can improve the bioavailability of curcumin by 2000 percent or more.

More Black Pepper Extract Benefits

Supports Healthy Cells

One way that black pepper can benefit us is by helping to support healthy cell growth. It does this by releasing antioxidants into our bloodstream, which can help protect against free radicals. Free radicals are highly reactive particles that can cause cell damage when left to roam within our bodies. This may be why people who consume more black pepper may experience fewer skin anomalies, such as wrinkles and liver spots.

Improves Digestion

Consuming black pepper also increases the amount of hydrochloric acid released into the stomach. A higher acid content helps the stomach digest foods more efficiently, which may be adding black pepper to food regularly can help reduce instances of colic, diarrhea and constipation. The spicy nature of black pepper also promotes sweating and more frequent urination, which helps flush toxins and excess fluids from the body. The flushing of toxins helps reduce the risks of developing more severe gastrointestinal problems.

Helps Maintain a Healthy Weight

Black Pepper Extract Benefits: Boost Nutrient Absorption and More 1In addition to helping the body flush excess water and toxins from the body, black pepper plants assist in maintaining a healthy weight in another way. Black pepper possesses an outer layer that works to help support the breakdown of fat cells in the body when it’s ingested. Fat cells that are broken down are more easily digested, making it more efficient for the body to process those cells. This means they will be used for energy and the waste will be flushed rather than having the whole cells stored to cause weight gain.

May Aid in Cases of Vitiligo

Vitiligo is a type of skin condition that inhibits pigmentation and gives some people a paler or whiter skin tone. A study conducted at Oregon Health & Science University found that pepperine helps the body produce melanocytes, which help to produce melanin. In turn, melanin makes it easier for the skin to darken and tan. In fact, a topical solution derived from piperine and used in combination with UV light therapy can help reduce the risk of developing skin cancer.

Improves Respiration

If you’re a fan of spicy foods, you already know that strong dishes help clear the sinuses and improve breathing. this is because the pepper acts as an expectorant, which breaks up mucus and phlegm in the sinus cavities. As you’re prompted to sneeze or cough, you expel those contaminants, which helps clear out the respiratory tract. Additionally, by removing these substances from the body, you may also be reducing the risk of illness or infection. If you’re easily congested or experience breathing difficulties, ingesting more black pepper may help.

While there are many more benefits of ingesting black pepper extract, the benefits listed here may be the most advantageous. By slowing down the digestive process, black pepper helps us gain the benefits of other foods we eat and the natural supplements we rely upon to stay healthy. By adding black pepper to more foods, we’re likely making those foods even more useful to our bodies.

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Filed Under: Cellular Health, Diet & Nutrition, Digestive Health, Metabolism, Skin Health

Exercise Affects Gut Bacteria, Regardless of Diet

Nov 14 by Ewcopywriting

In the past year, scientists have examined how exercise alone has the power to alter the bacterial balance of the gut. Now, a group of researchers taking a poke at further unpacking the mechanisms behind how exercise affects gut bacteria have focused their research efforts on endurance exercise in particular. According to a new study, irrespective of changes to one’s diet, endurance training increases the production of metabolism-boosting microbes while decreasing the presence of those known to cause inflammation. The new study has been published and is now available in the scientific journal Frontiers in Microbiology.

Exercise Changes the Microbial Composition of the Gut

Exercise Affects Gut Bacteria, Regardless of Diet 2In late 2017, researchers from the University of Illinois conducted a pair of studies that were designed to help isolate changes in gut bacteria that were caused by exercise as opposed to other factors like antibiotic consumption or dietary intake. The two studies provided first-time evidence of exercise’s ability to change the microbial composition of the gut on its own accord. Their research successfully demonstrated in both mouse and human trials that exercise alone was enough to alter the types of bacteria present within the gut in a beneficial manner.

The team’s research shown exercise to increase the number of microbes that produce short-chain fatty acids (SCFAs). In particular, it created a significant increase in a particular SCFA — butyrate — that is known to boost energy, encourage the health of intestinal cells and reduce inflammation. According to their data, exercise may also increase the body’s resistance to inflammatory bowel diseases like ulcerative colitis. The levels again declined when the subjects returned to sedentary lifestyles.

One interesting observation was that the lean subjects were found to have the largest increase in their SCFA levels, likely because their levels were significantly lower at the start of the study. The ratios of microbes present in the guts of obese participants and lean participants differed throughout the entire duration of the study, a clear demonstration that the gut microbiota of a lean person versus an obese person will respond very differently to exercise.

Narrowing in on Endurance Exercise’s Effects on Gut Bacteria

In a collaborative effort among institutions, scientists from the University of Jyväskylä, the University of Turku and nonprofit research organization FISABIO came together to delve deeper into how exercise affects the gut microbiota. In order to conduct their experiments, the team of researchers developed a six-week exercise program for overweight women who were previously sedentary but otherwise healthy. Over the six-week window, the participants took part in three separate endurance training sessions each week utilizing a bicycle ergometer. The researchers controlled the endurance training intensity by monitoring the heart rates of the participants. The women were asked not to make any lifestyle changes — such as dietary intake or alcohol consumption — during the study in order to zero in on the effects of exercise.

Throughout the study, the researchers analyzed gut composition and changes in gene activity utilizing 16S ribosomal RNA sequencing technology. The team observed that overall, after only six weeks of endurance training, there was a notable decrease in microbes known to cause inflammation (Proteobacteria) and an increase in those known to boost metabolism (Akkermansia).

In regards to gene functionality, there was little change observed over the course of the study. Pekkala commented, “The abundance of the functional genes did not change much, which was perhaps to be expected because the diet did not change during training. If the training period had been longer, greater effects probably would have been seen.”

The Cardiometabolic Benefits of Endurance Exercise: Could Akkermansia Microbes Be the Driving Force?

Exercise Affects Gut Bacteria, Regardless of Diet 1While there was no significant weight loss from the endurance training alone, there were other notable health benefits of the activity. According to research fellow Satu Pekkala from the University of Jyväskylä, “We found that phospholipids and cholesterol in VLDL particles decreased in response to exercise.” She explains, “These changes are beneficial for cardiometabolic health because VLDL transports lipids from the liver to peripheral tissues, converts into ‘bad’ LDL cholesterol in the circulation, and thus has detrimental cardiovascular effects.”

The endurance training regimen also decreased the activity of what is referred to as “vascular adhesion protein-1”, a molecule whose presence is associated with increased inflammation, though the authors report they were unable to determine the underlying mechanism for this in their study.

Other studies have observed a higher prevalence of Akkermansia bacteria in people who are more physically active, with some researchers looking to prove how Akkermansia may be a viable preventative against diabetes and obesity. But whether the alteration in gut microbes is the force behind all the beneficial changes observed here is a matter for future investigations. As Pekkala notes, “[More] studies are needed to prove that Akkermansia might mediate some of the health benefits of exercise.”

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Filed Under: Blood Sugar/Glucose Metabolism, Digestive Health, Heart Health, Metabolism

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